Key result
Predictive genetic testing identifies family members for clinical evaluation who harbor a pathogenic variant following cardiac arrest or sudden unexpected death.
Provides a pathway for applying genetic testing and clinical evaluation for family members following a cardiac arrest or sudden unexpected death.
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May support cascade screening in relatives after sudden death; hypothesis-generating and requires prospective validation before practice change.
The pathway for the application of genetic and clinical evaluation following cardiac arrest or sudden unexpected death. The broken arrow indicates weaker evidence. *Predictive genetic testing will identify family members for clinical evaluation who harbour a pathogenic or likely pathogenic variant when this has been identified in a family. Otherwise, all first-degree relatives should be offered clinical evaluation.1+Only genes with robust disease associations should be included.
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Elijah R. Behr (2022) conducted a review in Cardiac arrest and sudden unexpected death. Genetic and clinical evaluation was evaluated. Predictive genetic testing identifies family members for clinical evaluation who harbor a pathogenic variant following cardiac arrest or sudden unexpected death.
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