Key result
Pharmacologic treatments such as cromolyn, baclofen, theophylline, sulindac, and local anesthetics may be considered for ACE inhibitor-induced cough when discontinuing the ACE inhibitor is not ideal.
Why the study?
Does pharmacologic treatment (cromolyn, baclofen, theophylline, sulindac, local anesthetics) improve ACE inhibitor-induced cough in patients who cannot discontinue the ACE inhibitor?
Does pharmacologic treatment (cromolyn, baclofen, theophylline, sulindac, local anesthetics) improve ACE inhibitor-induced cough in patients who cannot discontinue the ACE inhibitor?
Pharmacologic agents like cromolyn, baclofen, and sulindac offer potential management strategies for ACE inhibitor-induced cough when ACE inhibitor discontinuation is not feasible.
Answers are grounded in this paper and cite their sources.
Cautious consideration only if ACE inhibitor must continue; leaves open efficacy pending randomized trials.
Angiotensin-converting enzyme (ACE) inhibitors are widely administered to treat numerous medical conditions. Although they are generally well tolerated, they are associated with a dry cough that can lead to discontinuation of treatment. Data concerning the frequency, onset, and clinical effects vary among the agents. When discontinuing the ACE inhibitor is not an ideal option, pharmacologic treatment of the cough may be considered, such as cromolyn, baclofen, theophylline, sulindac, and local anesthetics.
No takes yet. Share an insight, caveat, or question.
Luque et al. (1999) conducted a review in ACE inhibitor-induced cough. Pharmacologic treatment (cromolyn, baclofen, theophylline, sulindac, local anesthetics) was evaluated. Pharmacologic treatments such as cromolyn, baclofen, theophylline, sulindac, and local anesthetics may be considered for ACE inhibitor-induced cough when discontinuing the ACE inhibitor is not ideal.
Synapse has enriched 10 related papers. Consider them for comparative context: