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May 1, 2018The Indian Journal of Medical Research4 citationsOpen Access

Molecular characterization of hepatitis A virus from children hospitalized at a tertiary care centre in northwest India

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Why the study?

What are the prevalent Hepatitis A virus genotypes in children hospitalized with acute viral hepatitis in northwest India?

Population

1269 children clinically suspected of viral hepatitis, hospitalized at a tertiary care centre in northwest…

Design

Cross-sectional

Key result

Among 1,269 children hospitalized with acute viral hepatitis, 50.6% were positive for anti-HAV IgM, and all 44 sequenced samples were identified as genotype IIIA.

Authors

BMBharti MalhotraAKAnu KanwarPRP. V. Janardhan Reddy

Discussion

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Overview

May inform regional HAV prevention in northwest India; leaves open broader surveillance needs before guiding national policy.

Study Design

Type

Cross-Sectional (n=1,269)

Multicenter

No

Structured PICO

What are the prevalent Hepatitis A virus genotypes in children hospitalized with acute viral hepatitis in northwest India?

P
Population
1,269 children aged 0-15 years hospitalized with signs and symptoms of acute viral hepatitis at a tertiary care center in northwest India between 2012 and 2014.
E
Exposure
Screening for anti-HAV IgM, RNA extraction, nested PCR, and nucleotide sequencing
O
Outcome
Identification of Hepatitis A virus (HAV) genotypessurrogate

Hepatitis A genotype IIIA is the predominant cause of acute viral hepatitis among children in northwest India, particularly affecting those under five years of age during July to September.

Limitations

  • All samples were from hospitalized patients, with more severe disease, and higher than normal ALT and AST levels.
  • Patients were not followed up, so information about the clinical course of the disease was not available.
  • Did not study non-hospitalized patients or samples from outbreak cases.

Cite This Study

Malhotra et al. (2018) conducted a cross-sectional in Acute viral hepatitis (n=1,269). Hepatitis A virus infection was evaluated on Anti-HAV IgM positivity. Among 1,269 children hospitalized with acute viral hepatitis, 50.6% were positive for anti-HAV IgM, and all 44 sequenced samples were identified as genotype IIIA.

synapsesocial.com/papers/6a997d9efd3b4a2f12c72eb0https://doi.org/10.4103/ijmr.ijmr_1910_15
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Also Consider

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  5. 5Cocirculation of and coinfections with hepatitis A virus subgenotypes IIIA and IB in patients from Pune, western India2007 · 20 citations