Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 12, 2015PLoS ONEOpen Access

Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates

View Full Paper
Ask AI
Bookmark
Share

Authors

DBDaniel BolocSCSergio Castillo-LaraGMGemma Marfany

Discussion

Loading...

Member takes

Overview

Network analysis uncovers key molecular pathways in retinitis pigmentosa and retinal dystrophies, highlighting novel candidate disease genes for targeted therapy.

Key Points

  • Build an integrated interactome network for retinitis pigmentosa and related retinal dystrophies to identify novel candidate disease genes and elucidate underlying biological pathways.
  • Aggregated gene-protein interaction data from high-throughput databases (BioGRID and STRING), curated sources (iHOP), and syntactical text-mining of published literature.
  • Used known retinitis pigmentosa and Leber congenital amaurosis causative genes as baits to query the interactome and distill minimal networks of close neighbors.
  • Constructed RPGeNet, an interactive platform designed to explore molecular networks connecting syndromic and non-syndromic retinal disease genes.
  • Integrated tissue-specific expression and phenotypic data over distilled interaction pathways to highlight key degeneration mechanisms and unassigned disease candidates.

Cite This Study

Boloc et al. (2015) studied this question.

synapsesocial.com/papers/6a997eec2f2c4aeb9b56c76ehttps://doi.org/10.1371/journal.pone.0135307
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome Wide Pleiotropic Analysis Reveals Shared Genetic Architecture and Pathological Basis Between Retinitis Pigmentosa and Relevant Ocular Comorbidities2026
  2. 2Inferring genetic associations of programmed cell death genes with retinitis pigmentosa through multimodal Mendelian randomization2026
  3. 3Causal Relationship Between Blood Proteome and Retinitis Pigmentosa: A Mendelian Randomization Study2026
  4. 4Mapping the intellectual landscape and emerging trends of retinitis pigmentosa research2026
  5. 5The genotype-phenotype association of retinitis pigmentosa in a Chinese population: Analysis of three new cases and literature review2025