Key result
Serum IGF-1 levels were significantly elevated in the early post-myocardial infarction period compared to healthy controls (243.2 vs 177.2 ng/mL, p=0.001), but did not correlate with echocardiographic measurements.
Why the study?
Only limited studies have investigated the relationship between serum IGF-1 and IGFBP-3 levels and left ventricular functions following acute myocardial infarction.
Are serum IGF-1 and IGFBP-3 levels altered in the early stage following acute myocardial infarction, and do they correlate with left ventricular dysfunction or in-hospital cardiac events?
Case-Control (n=91)
Are serum IGF-1 and IGFBP-3 levels altered in the early stage following acute myocardial infarction, and do they correlate with left ventricular dysfunction or in-hospital cardiac events?
Absolute Event Rate: 243.2% vs 177.2%
p-value: p=0.001
Serum IGF-1 levels are significantly elevated in the early phase of acute myocardial infarction but do not appear to predict early left ventricular dysfunction or in-hospital cardiac events.
May link IGF-1/IGFBP-3 to post-AMI LV function; leaves open any prognostic role pending prospective validation.
Background: Insulin-like growth factor (IGF) is the primary mediator of growth hormone. IGF-1 may have an important role in protecting the myocardial functions following an acute myocardial infarction (AMI). Literature reveals only a limited number of studies investigating the relationship between the serum IGF-1/IGF binding protein-3 (IGFBP-3) levels and the left ventricular functions post AMI. We aimed to determine IGF-1 and IGFBP-3 levels and evaluate their effect on cardiac functions post AMI.Material and Method: Sixty five patients who were included in the study and the control group had 26 patients. Blood samples of the patients were obtained on the second day of their admission. The patients underwent echocardiographic examination on the 7th day of their hospitalization.Results: The serum IGF-1 and IGFBP-3 levels of the patient group were higher than those of the control group; however only IGF-1 levels were statistically significant (243,2±87,9 ng/mL versus 177,2±81,8 ng/mL p=0,001). The increase in the wall thickness and LV chamber size did not correlate with the decrease in LVEF and IGF-1/IGFBP-3 levels. The patients who had minor cardiac events had lower IGF-1 levels but this was not statistically significant (210.5±88.5 versus 253.1±86.1 p>0.05). Conclusion: IGF-1 and IGFBP-3 levels elevated following an the early AMI, but these markers were not correlated with the echocardiographical measurements in early post MI period.
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Yılmaz et al. (2019) conducted a case-control in Acute myocardial infarction (n=91). Acute myocardial infarction vs. Healthy controls was evaluated on Serum IGF-1 levels (p=0.001). Serum IGF-1 levels were significantly elevated in the early post-myocardial infarction period compared to healthy controls (243.2 vs 177.2 ng/mL, p=0.001), but did not correlate with echocardiographic measurements.
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