The bioguided fractionation of the crude extracts of Lychnophora passerina (Mart. ex DC) Gardn., L. pinaster Mart. and L. trichocarpha Spreng. led to the isolation of four compounds active against the trypomastigote forms of Trypanosoma cruzi: the sesquiterpene lactones goyazensolide (1), eremantholide C (2), and lychnopholide (3) and a new caryophyllene derivative, which was named lychnophoic acid (4).
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Oliveira et al. (1996) studied this question.