Key result
Deep RNA sequencing of skeletal muscle tissue revealed an absence of viral signatures in dermatomyositis.
Why the study?
Type I interferons play a major role in dermatomyositis pathogenesis and certain acute viral infections trigger similar responses, prompting investigation into possible causative viruses.
Deep RNA sequencing of muscle tissue from patients with dermatomyositis did not detect causative viral signatures, suggesting viruses may not be directly present in the muscle despite the type I interferon response.
Hypothesis-generating for viral triggers in DM; leaves open whether acute infections initiate the conserved type I IFN response.
Type I interferons (IFN) play a major role in the pathogenesis of both juvenile and adult DM. The IFN response is remarkably conserved between DM subtypes classified by specific autoantibodies. Certain acute viral infections are accompanied by a prominent type I IFN response involving similar downstream mechanisms as in DM. Aiming to elucidate the pathogenesis of DM in skeletal muscle tissue, we used deep RNA sequencing and a host depletion approach to detect possible causative viruses.
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Corman et al. (2023) studied Dermatomyositis. Deep RNA sequencing was evaluated on Detection of causative viruses. Deep RNA sequencing of skeletal muscle tissue revealed an absence of viral signatures in dermatomyositis.
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