Key result
Type I IFN-dependent transcripts and endosomal Toll-like receptors were significantly upregulated in muscle biopsies from patients with idiopathic inflammatory myopathies compared to controls.
Population
76 muscle biopsies, including 47 from patients with idiopathic inflammatory myopathies, 10 dystrophinopathic…
Comparison
Gene expression profiling vs Control muscle biopsies
Design
Case-control
Authors
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Supports innate immune activation in IIM; hypothesis-generating and should not yet change practice.
Observational (n=76)
Type I interferon-induced molecules and endosomal Toll-like receptors are significantly upregulated in idiopathic inflammatory myopathies, suggesting a role for innate immunity in their pathogenesis.
Cappelletti et al. (2011) conducted an observational in Idiopathic inflammatory myopathies (JDM, adult dermatomyositis, PM) (n=76). Idiopathic inflammatory myopathies vs. Control muscle biopsies was evaluated on Expression of type I IFN-dependent genes and Toll-like receptors. Type I IFN-dependent transcripts and endosomal Toll-like receptors were significantly upregulated in muscle biopsies from patients with idiopathic inflammatory myopathies compared to controls.
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