Key result
Active dermatomyositis and polymyositis were associated with significant up-regulation of type I interferon-inducible genes in blood, which correlated with disease activity.
Population
44 patients with dermatomyositis, polymyositis, inclusion body myositis, myasthenia gravis, or genetically…
Design
Cross-sectional
Authors
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May support blood-based activity monitoring in DM/PM; leaves open prospective validation and therapeutic targeting.
Observational (n=56)
Type I interferon-inducible gene expression in blood is significantly up-regulated in active dermatomyositis and polymyositis and correlates with disease activity, suggesting its potential as a biomarker.
Walsh et al. (2007) conducted an observational in Inflammatory myopathies (dermatomyositis, polymyositis, inclusion body myositis) (n=56). Dermatomyositis and polymyositis vs. Inclusion body myositis, other myopathies, and healthy volunteers was evaluated on Expression of type I interferon-alpha/beta-inducible genes in blood. Active dermatomyositis and polymyositis were associated with significant up-regulation of type I interferon-inducible genes in blood, which correlated with disease activity.
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