What type of study is this?

This is a Differential Gene Expression study (also classified as: Gene Set Enrichment Analysis, Observational).

September 10, 2025Scientific ReportsOpen Access

Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis

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Differential gene expression profiles reveal unique immune responses in myositis, suggesting distinct pathways from dermatomyositis.

Differential gene expression analysis identified 93 genes that distinguish irMyositis from dermatomyositis and healthy controls.
GSEA indicated type-II interferon signaling was specifically upregulated in irMyositis, differing from the type-I interferon response in DM.
The study utilized the NanoString nCounter PanCancer Immune Profiling Panel for gene expression and pathway enrichment comparative analyses.
Findings highlight significant differences in immune responses underlying irMyositis, implying novel insights into immunotherapy-related adverse events.

Röckel et al. (2025) studied this question.

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