Key result
Computer simulations demonstrated that severe stenosis at the inner wall of a curved artery causes dramatic downstream flow changes, including flow separation with low and oscillating wall shear stress.
Computational modeling suggests that stenosis at the inner wall of curved arteries alters downstream hemodynamics, potentially promoting new plaque formation at the outer wall.
Stenosis location in curved arteries may influence downstream plaque sites; hypothesis-generating and requires human validation before clinical consideration.
The influence of stenosis on the pulsatile blood flow pattern in curved arteries with stenosis at inner wall was investigated by computer simulations. Numerical calculations were performed with various values of physiological parameters to examine the effect of a stenosis on the hemodynamic characteristics such as secondary flow, flow separation, wall shear stress (WSS) and pressure drop. The results demonstrated that when the severity of a stenosis at the inner wall of a curved artery reaches a certain level, the flow pattern in the downstream of the artery shows a dramatic change compared to that of a curved artery with no stenosis. According to previous studies, a flow separation occurs at the inner wall of the bend in a curved artery. The present work reports an analysis of such a flow separation area at the inner wall of the post stenosis region in curved arteries with a stenosis. In addition, another area of flow separation with low and oscillating WSS and blood pressure at the outer wall in a downstream tube was also found and investigated. The observed characteristic change of the flow downstream may suggest a formation of a new plaque at the outer wall downstream.
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Biyue Liu (2006) studied Stenosis in curved arteries. Stenosis at the inner wall of a curved artery vs. Curved artery with no stenosis was evaluated on Hemodynamic characteristics (secondary flow, flow separation, wall shear stress, and pressure drop). Computer simulations demonstrated that severe stenosis at the inner wall of a curved artery causes dramatic downstream flow changes, including flow separation with low and oscillating wall shear stress.
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