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Monensin inhibited methanogenesis from formate but not from H(2)-CO(2) by resting-cell suspensions of Methanobacterium formicicum. The antibiotic severely inhibited growth on formate. The lag phase of H(2)-CO(2)-grown cultures was prolonged by monensin, but these cultures recovered from the initial inhibition. The recovery did not result from the development of a monensin-resistant population or inactivation of the antibiotic.
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Dellinger et al. (1984) studied this question.
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