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An aldol condensation is the key to the eight-step linear synthesis of 23-oxa analogues of OSW-1 (e.g. 2) in more than 20 % overall yield from the industrially produced steroid 1. Compound 2 is up to 2000 times more potent than cisplatin as an inhibitor of tumor cell growth.
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Shi et al. (2004) studied this question.
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