Key result
Angiosarcoma was not associated with HHV-8, with 0% of angiosarcoma cases testing positive compared to 100% of epidemic Kaposi's sarcoma controls.
Why the study?
Is HHV-8 associated with angiosarcoma in HIV-negative patients?
Case-Control
Is HHV-8 associated with angiosarcoma in HIV-negative patients?
Answers are grounded in this paper and cite their sources.
This study confirms that HHV-8 is not associated with the pathogenesis of angiosarcoma in HIV-negative patients.
BACKGROUND:: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE:: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS:: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls. RESULTS:: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was. CONCLUSION:: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
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Avancini et al. (2016) conducted a case-control in Angiosarcoma. Angiosarcoma vs. Epidemic Kaposi's sarcoma was evaluated on Presence of HHV-8. Angiosarcoma was not associated with HHV-8, with 0% of angiosarcoma cases testing positive compared to 100% of epidemic Kaposi's sarcoma controls.
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