Recently, we have identified a hydroxyproline- containing protein(s) in human plasma (1) and developed a specific method for its assay (2). The behavior of this protein (hyproprotein) as shown in precipitation and gel filtration experi- ments indicates that it is a large molecule; its resistance to digestion by proteolytic enzymes suggests further that it may be a form of collagen As part of a program of study to determine the significance and possible origin of this circu- lating protein, a survey was made of plasma hypro- protein levels in a large number of normal sub- jects and in patients with a variety of clinical disorders. Also, comparisons were made with the levels of excretion in the urine of hydroxyprolinecontaining peptides.
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LeRoy et al. (1965) studied this question.
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