Key result
Multisite atrial pacing provided no incremental benefit over right atrial pacing in reducing the number of paroxysmal atrial fibrillation episodes (mean 52 vs 77 episodes, NS).
Why the study?
Does multisite atrial pacing reduce episodes of paroxysmal atrial fibrillation compared with right atrial pacing in patients with drug refractory paroxysmal atrial fibrillation?
Population
20 patients with drug refractory paroxysmal atrial fibrillation paced for arrhythmia prevention alone, mean…
Comparison
Multisite atrial pacing for one month vs Right atrial pacing for one month
Design
RCT, randomised crossover study, single blinded
Follow-up
one month per pacing mode
Authors
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Multisite atrial pacing offers no advantage over right atrial pacing for paroxysmal AF; challenges rationale for multisite use and supports right atrial pacing as standard.
RCT (n=20)
Single-blind
randomized crossover
Does multisite atrial pacing reduce episodes of paroxysmal atrial fibrillation compared with right atrial pacing in patients with drug refractory paroxysmal atrial fibrillation?
Absolute Event Rate: 52% vs 77%
p-value: p=NS
Multisite atrial pacing does not provide incremental antiarrhythmic benefit over right atrial pacing for preventing episodes in patients with drug-refractory paroxysmal atrial fibrillation.
Terry Levy (2001) conducted an RCT in drug refractory paroxysmal atrial fibrillation (n=20). Multisite atrial pacing vs. Right atrial pacing was evaluated on Number of episodes of paroxysmal atrial fibrillation (p=NS). Multisite atrial pacing provided no incremental benefit over right atrial pacing in reducing the number of paroxysmal atrial fibrillation episodes (mean 52 vs 77 episodes, NS).
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