Key result
Preloading with 6% hydroxyethyl starch resulted in a significantly lesser drop in mean arterial pressure at 1 and 60 minutes compared to Ringer's lactate following spinal anaesthesia (p<0.05).
Why the study?
Does preloading with 6% Hydroxy ethyl starch prevent hypotension better than Ringer's lactate in patients undergoing spinal anaesthesia?
RCT (n=60)
Allocated into two groups
No
Does preloading with 6% Hydroxy ethyl starch prevent hypotension better than Ringer's lactate in patients undergoing spinal anaesthesia?
Preloading with 6% hydroxy ethyl starch is more effective than Ringer's lactate in attenuating, though not completely eliminating, hypotension following spinal anesthesia.
May attenuate post-spinal hypotension; hypothesis-generating from Level 3 data and requires RCT confirmation before practice change.
Hypotension during spinal anaesthesia is common and can cause significantmorbidity and mortality.Prior to spinal anaesthesia fluid administration isrecommended to reduce the incidence of hypotension and this is referred to aspreloading.Crystalloids and colloids are routinely tried as pre loading fluids but there is still considerable debate over their effectivenessas a pre loading.A comparative study was under taken to compare the hemodynamic changes of Ringers lactate v/s Hydroxy ethyl starch in 60 ASA grade-I &II patients posted for lower abdominal and lower limb elective surgeries and allocated into two groups.Each patient was administrated either Ringer's lactate solution at 10 ml/ Kg body or 6% Hydroxy ethyl starch at 10 ml/ Kg over a period of 20 minutes before spinal anaesthesia.Following spinal anaesthesia mean arterial pressure were recorded at regular intervals.We found that hydroxy ethyl starch is more effective than lactated Ringer's solution as a pre loading fluid in prevention of hypotension following spinal anesthesia.However, we also concluded that incidence of hypotension was only reduced but not completely eliminated in this study.
No takes yet. Share an insight, caveat, or question.
Imran et al. (2014) conducted an RCT in Spinal anaesthesia for lower abdominal and lower limb elective surgeries (n=60). 6% Hydroxy ethyl starch vs. Ringer's lactate solution 10 ml/Kg was evaluated on Mean arterial pressure drop following spinal anaesthesia (p=<0.05). Preloading with 6% hydroxyethyl starch resulted in a significantly lesser drop in mean arterial pressure at 1 and 60 minutes compared to Ringer's lactate following spinal anaesthesia (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: