Key result
CT perfusion demonstrated a sensitivity of 0.84 and specificity of 0.73 for detecting delayed cerebral ischemia, identifying patients who may benefit from targeted medical or intra-arterial therapy.
Why the study?
Does CT Perfusion accurately detect delayed cerebral ischemia and vasospasm in adult patients with aneurysmal subarachnoid hemorrhage?
Cohort (n=97)
Blinded to clinical and imaging data
No
Does CT Perfusion accurately detect delayed cerebral ischemia and vasospasm in adult patients with aneurysmal subarachnoid hemorrhage?
Effect estimate: Sensitivity 0.84 (95% CI 0.73-0.96)
CT Perfusion is a highly sensitive diagnostic tool for detecting vasospasm and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage, and Bayesian analysis can help identify patients who would benefit from treatment based on CTP results.
May support CTP-guided DCI therapy in aSAH; leaves open need for prospective outcome trials before practice change.
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Killeen et al. (2013) conducted a cohort in Aneurysmal Subarachnoid Hemorrhage (n=97). CT Perfusion (CTP) vs. Reference standard (clinical/imaging for DCI, DSA for vasospasm) was evaluated on Detection of delayed cerebral ischemia (DCI) (Sensitivity 0.84, 95% CI 0.73-0.96). CT perfusion demonstrated a sensitivity of 0.84 and specificity of 0.73 for detecting delayed cerebral ischemia, identifying patients who may benefit from targeted medical or intra-arterial therapy.
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