All articles of this category The bicyclo[4.3.1]decenone core of the ras -farnesyl protein transferase inhibitors CP-225,917 and CP-263,114 is prepared in 6 steps from cyclohexanone. The key step is an intramolecular Mukaiyama aldol reaction. CP-225,917 - CP-263,114 - anti-Bredt - bicyclo[4.3.1]decenone - Mukaiyama aldol
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Armstrong et al. (1998) studied this question.
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