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September 30, 2016Nature CommunicationsOpen Access

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

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Key result

Cyclic assembly of actin onto mitochondrial subpopulations induces local, Drp1-dependent fragmentation, while actin disassembly promotes rapid fusion and regional recovery of the tubular mitochondrial network.

Population

HeLa cells (live-cell imaging)

Comparison

Actin polymerization/depolymerization, and… vs Mitochondria without associated actin, or…

Design

Preclinical

Authors

AMAndrew S. MooreChildren’s Health Queensland Hospital and Health ServiceYWYvette C. WongNorthwestern UniversityCSCory L. SimpsonCalifornia Institute for Regenerative Medicine

Discussion

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Implication

Actin cycling may tune mitochondrial dynamics in cardiomyocytes; extends fission-fusion mechanisms but leaves clinical relevance open.

Structured PICO

P
Population
In vitro study using live-cell imaging of HeLa, COS-7, and primary human epidermal keratinocytes to investigate actin dynamics on mitochondrial networks.
E
Exposure
Actin polymerization/depolymerization, and pharmacological/genetic inhibition (Latrunculin B, CK-666, SMIFH2, Drp1-K38A)
C
Comparator
Mitochondria without associated actin, or control cells
O
Outcome
Mitochondrial fission and fusion dynamics (mitochondrial length, area, branching, and number)surrogate

Cyclic assembly of actin onto mitochondria modulates the fission/fusion balance, serving as an essential mechanism regulating mitochondrial network homeostasis.

Limitations

  • In vitro study using primarily immortalized cell lines
  • Focuses on cellular mechanisms without direct clinical outcomes

Cite This Study

Moore et al. (2016) studied Mitochondrial dynamics. Actin cycling vs. Actin-negative mitochondria was evaluated on Mitochondrial fission and fusion balance. Cyclic assembly of actin onto mitochondrial subpopulations induces local, Drp1-dependent fragmentation, while actin disassembly promotes rapid fusion and regional recovery of the tubular mitochondrial network.

synapsesocial.com/papers/6a99958cc3ab604adaaba139https://doi.org/10.1038/ncomms12886
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast2001 · 199 citations
  2. 2A Human Dynamin-related Protein Controls the Distribution of Mitochondria1998 · 739 citations
  3. 3Organization and dynamics of human mitochondrial DNA2004 · 391 citations
  4. 4An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF22013 · 843 citations
  5. 5Dynamic regulation of mitochondrial fission through modification of the dynamin‐related protein Drp12010 · 579 citations