Key result
Non-insulin-dependent diabetes mellitus was associated with a significantly higher prevalence of pancreatic vascular disease on postmortem angiography compared to controls (58% vs 20%, p=0.0001).
Why the study?
Is pancreatic vascular disease more common in subjects with non-insulin-dependent diabetes mellitus compared to controls?
Case-Control (n=96)
Is pancreatic vascular disease more common in subjects with non-insulin-dependent diabetes mellitus compared to controls?
Absolute Event Rate: 58% vs 20%
p-value: p=0.0001
Postmortem angiography reveals that atherosclerotic vascular disease in the feeding arteries of the pancreas is significantly more common in patients with NIDDM than in matched controls.
Pancreatic vascular disease may contribute to NIDDM progression; this Level 4 association leaves open causality and needs prospective validation.
We evaluated, from 96 postmortem angiographs, the main feeding arteries and degree of vascularity of the pancreas to discover to what extent atherosclerosis affects pancreatic blood supply in subjects with and without non-insulin-dependent diabetes mellitus (NIDDM). Patients with NIDDM more often showed intrapancreatic arteries with irregularities in the body-tail of the pancreas (p = 0.050) and more frequently demonstrated decreased vascularity in both the body-tail and the head of the pancreas (p < 0.001) than did the controls. When the arterial system from the aorta to the intrapancreatic branches was examined as a whole, 26 (58%) of the NIDDM patients and 10 (20%) of the controls (p = 0.0001) showed one or more of the following: >50% stenosis in the celiac or splenic artery, two or more irregular intrapancreatic branches, or a distinctly decreased degree of vascularity in the body-tail portion of the pancreas, the region responsible for most insulin secretion. Only 1 NIDDM patient, compared to 10 controls, showed a totally normal angiogram. In conclusion, vascular disease in the feeding arteries of the pancreas is more common in NIDDM patients than age- and gender-matched controls.
No takes yet. Share an insight, caveat, or question.
Kauppilla et al. (1998) conducted a case-control in Non-Insulin-Dependent Diabetes Mellitus (NIDDM) (n=96). Non-insulin-dependent diabetes mellitus (NIDDM) vs. Controls without NIDDM was evaluated on One or more of the following: >50% stenosis in the celiac or splenic artery, two or more irregular intrapancreatic branches, or a distinctly decreased degree of vascularity in the body-tail portion of the pancreas (p=0.0001). Non-insulin-dependent diabetes mellitus was associated with a significantly higher prevalence of pancreatic vascular disease on postmortem angiography compared to controls (58% vs 20%, p=0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: