Why the study?
Does intracoronary insulin infusion improve myocardial glucose metabolism similarly in ischemic heart disease patients with and without NIDDM?
Population
26 coronary disease patients with (n=13) and without (n=13) non-insulin-dependent diabetes mellitus (NIDDM)
Comparison
Intracoronary insulin infusion vs Coronary disease patients without NIDDM (controls)
Design
Cross-sectional
Authors
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Preserved myocardial glucose uptake response to insulin in NIDDM; supports organ-specific resistance but leaves open clinical relevance in ischemic heart disease.
Does intracoronary insulin infusion improve myocardial glucose metabolism similarly in ischemic heart disease patients with and without NIDDM?
Myocardial glucose metabolism remains responsive to insulin in patients with NIDDM and ischemic heart disease, suggesting insulin resistance is organ-specific and differs between muscle and vascular tissue.
Jagasia et al. (2001) studied this question.
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