Key result
Biostable polyurethane heart valves (EV3.34 and EV3.35) implanted in sheep for up to 9 months showed no evidence of biodegradation and retained their mechanical properties compared to controls.
Why the study?
Do biostable polyurethane heart valves maintain their mechanical and morphological properties after implantation in a sheep model?
Population
12 young adult (18 month) sheep
Comparison
Implantation of flexible trileaflet heart valves… vs Unimplanted control material
Design
Preclinical
Follow-up
6 and 9 months
Authors
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Retains properties in sheep up to 9 months; leaves open translation to human implants.
Do biostable polyurethane heart valves maintain their mechanical and morphological properties after implantation in a sheep model?
Novel biostable polyurethane heart valves demonstrate resistance to biodegradation and retain mechanical properties up to 9 months in a sheep model, suggesting potential durability for structural heart interventions.
Bernacca et al. (2002) studied Heart valve replacement (n=12). Biostable polyurethane heart valve leaflets (EV3.34 and EV3.35) vs. Unimplanted control material was evaluated on Degradation of functional groups, surface morphology, and mechanical properties. Biostable polyurethane heart valves (EV3.34 and EV3.35) implanted in sheep for up to 9 months showed no evidence of biodegradation and retained their mechanical properties compared to controls.
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