Key result
LPL attached to chylomicrons does not enhance their binding to isolated hepatocytes, but hydrolysis by LPL is required for recognition and uptake, which occurs independently of apo E.
In a mouse model, the uptake of chylomicron remnants by hepatocytes requires prior hydrolysis by lipoprotein lipase but does not require apoprotein E mediation.
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May refine remnant clearance models; leaves open LPL hydrolysis relevance to human dyslipidemias.
Chang et al. (1996) studied this question. Lipoprotein lipase (LPL) attached to chylomicrons vs. Chylomicrons without bound LPL was evaluated on Binding and uptake of chylomicrons by hepatocytes. LPL attached to chylomicrons does not enhance their binding to isolated hepatocytes, but hydrolysis by LPL is required for recognition and uptake, which occurs independently of apo E.
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