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Choriocarcinoma, a highly malignant trophoblastic tumor, usually follows a normal or abnormal pregnancy and is called gestational choriocarcinoma. The nongestational form, known as primary choriocarcinoma, is extremely rare in men. Herein, we report the 18F-FDG and 68Ga-FAPI-04 PET/CT findings in a 56-year-old man with nongestational choriocarcinoma of unknown primary and multiple metastases. The lesions showed intense 18F-FDG uptake but limited 68Ga-FAPI-04 accumulation.
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Liu et al. (2026) studied this question.
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