Key result
Coronary slow flow in takotsubo syndrome was associated with higher long-term all-cause mortality compared to normal flow.
Why the study?
Patients with takotsubo syndrome may present with coronary slow flow, but its detailed clinical relevance and long-term impact remain poorly understood.
Does coronary slow flow predict long-term mortality in patients with Takotsubo syndrome?
Cohort (n=82)
Does coronary slow flow predict long-term mortality in patients with Takotsubo syndrome?
Coronary slow flow is present in about 40% of Takotsubo syndrome patients and is strongly associated with increased long-term all-cause mortality.
Answers are grounded in this paper and cite their sources.
Coronary slow flow may support risk stratification in takotsubo syndrome; hypothesis-generating and requires prospective validation.
Patients with takotsubo syndrome (TTS) may present coronary slow flow (CSF) in angiography performed in the acute myocardial infarction (MI). However, the detailed clinical relevance and its long-term impact remain poorly understood. Among 7771 MI patients hospitalized between 2012 and 2019, TTS was identified in 82 (1.1%) subjects. The epicardial blood flow was assessed with thrombolysis in myocardial infarction (TIMI) scale and corrected TIMI frame count (TFC), whereas myocardial perfusion with TIMI myocardial perfusion grade (TMPG). CSF was defined as TIMI-2 or corrected TFC > 27 frames in at least one epicardial vessel. CSF was identified in 33 (40.2%) TTS patients. In the CSF-TTS versus normal-flow-TTS group, lower values of left ventricular ejection fraction on admission (33.5 (25–40) vs. 40 (35–45)%, p = 0.019), more frequent midventricular TTS (27.3 vs. 8.2%, p = 0.020) and the coexistence of both physical and emotional triggers (9.1 vs. 0%, p = 0.032) were noted. Within a median observation of 55 months, higher all-cause mortality was found in CSF-TTS compared with normal-flow TTS (30.3 vs. 10.2%, p = 0.024). CSF was identified as an independent predictor of long-term mortality (hazard ratio 10.09, 95% confidence interval 2.12–48.00, p = 0.004). CSF identified in two-fifths of TTS patients was associated with unfavorable long-term outcomes.
No takes yet. Share an insight, caveat, or question.
Stępień et al. (2024) conducted a cohort in Takotsubo syndrome (n=82). Coronary slow flow (CSF) vs. Normal-flow was evaluated on Long-term all-cause mortality (HR 10.09, 95% CI 2.12-48.00, p=0.004). Coronary slow flow in takotsubo syndrome was associated with higher long-term all-cause mortality compared to normal flow.
Synapse has enriched 10 related papers. Consider them for comparative context: