2026 iCARDIO Alliance Global Implementation Guidelines on Ischemic Heart Disease

There are a number of guidelines on how to manage ischemic heart disease (IHD), but inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices restrict their global applicability. This underscores the need for universal recommendations that address the unique challenges faced by patients and healthcare providers worldwide. Our Global Guidelines emphasize the incorporation of novel therapies, while integrating standards of care with the most up-to-date evidence to enable clinicians to optimize IHD management. These Global Guidelines provide evidence-based recommendations that represent a group consensus considering the previously published guidelines that have reviewed many of the issues related to the management of IHD but have also provided recommendations on several issues where resource limitations may put constraints on the evaluation and treatments provided to patients with IHD. Such recommendations aim to guide situations when resources are somewhat limited or when resources are severely limited. Hence, this document presents a comprehensive update to IHD management guidelines, thereby aiming to provide a unified strategy for the management of IHD that is applicable to all cardiovascular care worldwide.