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n this issue of Circulation, Howard and colleagues 1 present a study on the risk of cardiovascular disease (CVD) by hysterectomy status using data from the Women's Health Initiative Observational Study. The purpose of this editorial is to put their work and its findings into context by reviewing the literature both on the epidemiology of hysterectomy, as well as on menopause, sex hormones, and blood loss, and their impact on the risk of CVD.
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Kate M. Brett (2005) studied this question.
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