Key result
Grape seed proanthocyanidins (GSPE) conferred cardiac protective and antioxidant effects against Ehrlich solid tumors in mice, with cotreatment showing better improvement than posttreatment.
Why the study?
The study aimed to explore how cardiac toxicity, damage, oxidative stress, and changes in TNFα and apoptotic P53 expression triggered by Ehrlich solid tumors could be countered with grape seed proanthocyanidins.
Does grape seed proanthocyanidins (GSPE) reduce cardiac toxicity and oxidative stress in mice with Ehrlich solid tumors?
Does grape seed proanthocyanidins (GSPE) reduce cardiac toxicity and oxidative stress in mice with Ehrlich solid tumors?
Grape seed proanthocyanidins demonstrated cardioprotective and antioxidant effects against tumor-induced cardiac toxicity in a mouse model.
Hypothesis-generating for GSPE cardioprotection in tumor models; leaves open translation to human cancer patients.
Examination of the antineoplastic effects of a range of chemical compounds is often undertaken via the transplantable tumor model of Ehrlich solid tumor (EST), which is a simulation of breast cancer. The purpose of this study was to explore how cardiac toxicity, damage, oxidative stress, and changes in the expressions of TNFα and apoptotic P53 triggered by EST could be countered with grape seed proanthocyanidins (GSPE). To that end, 50 female mice were used, with arbitrary and equal distribution into five groups, namely, the control group (G1), GSPE group (G2), EST group (G3), GSPE + EST (G4; cotreatment consisted of mice that received GSPE treatment at the beginning of EST induction over a period of 14 days), and EST + GSPE (G5; posttreatment consisted of mice with EST that received GSPE treatment for 14 days following the 14 days since the induction of EST). By comparison with the control group, the EST group had significantly higher levels of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), creatine kinase MB (CK‐MB), myoglobin, cardiac TBARS, nitric oxide (NO), total thiol and hydrogen peroxide, cardiac damage, and expression of P53 and TNFα. On the other hand, the EST group had significantly lower levels of cardiac catalase and total antioxidant (TAC) than the control group. Furthermore, better improvement in cardiac toxicity, oxidative stress, damage, apoptosis, and TNFα expressions was displayed by the cotreated (GSPE + EST) group than by the posttreated (EST + GSPE) group. This led to the conclusion that GSPE conferred cardiac protective and antioxidant effects against EST. This finding calls for more investigation on the benefits of grape seeds as adjuvant agents to prevent and treat cardiac toxicity.
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Maha A. Aldubayan (2020) studied Ehrlich solid tumor (EST) induced cardiac toxicity (n=50). Grape seed proanthocyanidins (GSPE) vs. EST without GSPE and healthy controls was evaluated on Cardiac toxicity, damage, oxidative stress, and expressions of TNFα and apoptotic P53. Grape seed proanthocyanidins (GSPE) conferred cardiac protective and antioxidant effects against Ehrlich solid tumors in mice, with cotreatment showing better improvement than posttreatment.
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