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Some tri‐ and hexapeptides containing hydroxyproline and serine were synthesized using the 2‐methoxyethoxymethyl group for the protection of the hydroxyl function. For N‐protection not only the NpS and the Z group but also the Boc group can be used. As compared to the But group the Mem group is much more stable towards TFA. Application of Mem protection allows a complete deblocking of the Boc group without affecting the Mem group.
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Vadolas et al. (1985) studied this question.
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