Key result
Low-dose spironolactone prevented the development of Western diet-induced diastolic dysfunction in female mice, significantly improving isovolumic relaxation time compared to placebo.
Why the study?
Does spironolactone prevent Western diet-induced diastolic dysfunction in female C57BL6J mice?
Does spironolactone prevent Western diet-induced diastolic dysfunction in female C57BL6J mice?
Absolute Event Rate: 16.8% vs 22.3%
p-value: p=<0.05
Low-dose spironolactone prevents the development of diastolic dysfunction induced by a Western diet in a female mouse model.
No immediate clinical implications for human HFpEF; hypothesis-generating for mineralocorticoid antagonism in diet-induced diastolic dysfunction.
Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption of a Western Diet (WD) high in fat, fructose, and sucrose. Female C57BL6J mice were fed a WD with or without Sp (1 mg·kg(-1)·day(-1)). After 4 mo on the WD, mice exhibited increased body weight and visceral fat, but similar blood pressures, compared with control diet-fed mice. Sp prevented the development of WD-induced DD, as indicated by decreased isovolumic relaxation time and an improvement in myocardial performance (
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Habibi et al. (2015) studied Western diet-induced diastolic dysfunction (n=29). Spironolactone vs. Placebo (Western diet alone) was evaluated on Isovolumic relaxation time (IVRT) in ms (p=<0.05). Low-dose spironolactone prevented the development of Western diet-induced diastolic dysfunction in female mice, significantly improving isovolumic relaxation time compared to placebo.
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