Sudden Death After Methylprednisolone Pulse Therapy

Letters and Corrections1 July 1981Sudden Death After Methylprednisolone Pulse TherapyTOMAS S. BOCANEGRA, M.D., M. OSWALDO CASTANEDA, M.D., LUIS R. ESPINOZA, M.D., FRANK B. VASEY, M.D., BERNARD F. GERMAIN, M.D.TOMAS S. BOCANEGRA, M.D., M. OSWALDO CASTANEDA, M.D., LUIS R. ESPINOZA, M.D., FRANK B. VASEY, M.D., BERNARD F. GERMAIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-122_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Corticosteroid pulse therapy is becoming increasingly popular for the treatment of immune-mediated disorders. The current enthusiasm for its use in different clinical settings, including disease of children (1), rests on the apparent absence of serious side effects (2, 3). In a recent editorial in your journal, however, Hess and Kammen (4) stressed the unresolved questions about this modality of treatment, including its safety. We wish to report the cases of two patients who had cardiac arrest in the 24 hours after pulse therapy.Case 1:A 44-year-old man developed skin rash, muscle weakness, pleuritic chest pain, personality...References1. MILLER J. Prolonged use of large intravenous steroid pulses in the rheumatic diseases of children. Pediatrics. 1980;65:989-94. MedlineGoogle Scholar2. BOLTONCOUSER WW. Intravenous pulse methylprednisolone therapy of acute crescentic rapidly progressive glomerulonephritis. Am J Med. 1979;66:495-502. CrossrefMedlineGoogle Scholar3. LIEBLINGLIEBMCLAUGHLIN MEK. Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. Ann Intern Med. 1981;94:21-6. LinkGoogle Scholar4. HESSKAMMEN EP. Pulse therapy in rheumatoid arthritis. Ann Intern Med. 1981;94:128-9. Editorial. LinkGoogle Scholar5. GARRETPAULUS RH. Complications of intravenous methylprednisolone pulse therapy. Arthritis Rheum. 1980;23:677. Abstract Google Scholar6. STUBBSMORELL SR. Intravenous methylprednisolone sodium succinate: adverse reactions reported in association with immunosuppressive therapy. Transplant Proc. 1973;5:1145-6. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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MOSES, D.O., ALICE MCCORMICK, D.O., WILLIAM NICKEY, D.O. 1 July 1981Volume 95, Issue 1Page: 122-122KeywordsChildrenCorticosteroid therapyHeartHeart rateIschemiaMusclesRashesSafety Issue Published: 1 July 1981 PDF downloadLoading ...