Key result
Intravenous infusion of isoprenaline decreased the mean peripheral platelet count to 82% of baseline in healthy volunteers, an effect that was blocked by pretreatment with propranolol.
Why the study?
Does isoprenaline infusion affect peripheral platelet count in healthy male volunteers?
Population
5 healthy male volunteers aged 24-39 (mean 30) years
Comparison
Intravenous infusion of isoprenaline for 20… vs Baseline platelet count, and isoprenaline…
Design
Other
Follow-up
20 minutes post-infusion
Authors
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Isoprenaline may lower platelet counts in healthy volunteers; leaves open relevance to patients or clinical outcomes.
Does isoprenaline infusion affect peripheral platelet count in healthy male volunteers?
Beta-receptor stimulation with isoprenaline decreases peripheral platelet count, an effect that is mediated by beta-receptors as it is blocked by propranolol.
Kutti et al. (1973) conducted a letter in Healthy (n=5). Isoprenaline vs. Isoprenaline with propranolol pretreatment was evaluated on Peripheral platelet count. Intravenous infusion of isoprenaline decreased the mean peripheral platelet count to 82% of baseline in healthy volunteers, an effect that was blocked by pretreatment with propranolol.
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