Key result
Patients with rheumatoid arthritis have a significantly higher risk of cardiovascular morbidity and mortality, particularly acute myocardial infarction, driven by both traditional risk factors and chronic systemic inflammation.
Rheumatoid arthritis significantly increases the risk of ischemic heart disease, highlighting the need for optimal control of both systemic inflammation and traditional cardiovascular risk factors.
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease of unknown etiology. Current knowledge supports that chronic inflammation represents a crucial risk factor without prior development of atherosclerosis. Thus, the epidemiological findings of patients with RA have demonstrated an expressive increase in cardiovascular morbidity and mortality. In addition, these patients present a higher prevalence of coronary risk factors and, when associated with poor prognostic factors, increase the risk of ischemic heart disease.
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Santos et al. (2019) conducted a review in Rheumatoid Arthritis. Rheumatoid arthritis vs. General population was evaluated. Patients with rheumatoid arthritis have a significantly higher risk of cardiovascular morbidity and mortality, particularly acute myocardial infarction, driven by both traditional risk factors and chronic systemic inflammation.
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