Parvovirus infections of mice and rats

The recent discovery of new rodent parvoviruses indicate that the properties and effects of these viruses are more diverse than previously thought. They include virus and host-dependent effects on pathogenicity, persistent infection, immunomodulation and oncosuppression. The diversity and prevalence of rodent parvoviruses and their potential for interference with animal-based research present compelling reasons for investigating parvoviral–host interactionsin vivo. Such studies should also improve understanding of parvoviral biology for the benefit of both human and animal health.