What question did this study set out to answer?

To determine whether the human growth hormone variant gene (GH-V), previously considered nonfunctional, is actively expressed in placental tissue and codes for human placental growth hormone.

March 1, 1987The Journal of Clinical Endocrinology & Metabolism

Expression of the Growth Hormone Variant Gene in Human Placenta

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Authors

FFFrançis FrankenneRoche (Switzerland)FRFrançoise Rentier‐DelrueUniversity of Liège MSMarie‐Louise ScippoUniversity of Liège

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Implication

Molecular study reveals active hGH-V gene expression in human placenta, indicating that placental growth hormone originates from this previously presumed silent variant.

Key Points

To determine whether the human growth hormone variant gene (GH-V), previously considered nonfunctional, is actively expressed in placental tissue and codes for human placental growth hormone.
Extracted messenger RNA from human placenta and from an hGH-secreting pituitary adenoma.
Performed dot-blot hybridization using synthetic polynucleotide probes complementary to unique sequence segments of the hGH-V and hGH-N genes.
Demonstrated strong, specific expression of the hGH-V gene in human placental tissue.
Detected hGH-V mRNA at very low levels in the pituitary adenoma, establishing that placental growth hormone is the primary product of the hGH-V gene.

Cite This Study

Frankenne et al. (1987) studied this question.

synapsesocial.com/papers/6a99adf41e9031f1530945db https://doi.org/10.1210/jcem-64-3-635

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Implication

Molecular study reveals active hGH-V gene expression in human placenta, indicating that placental growth hormone originates from this previously presumed silent variant.

Expression of the Growth Hormone Variant Gene in Human Placenta

Discussion

Member takes

Implication

Key Points

Cite This Study

Expression of the Growth Hormone Variant Gene in Human Placenta

Discussion

Member takes

Implication

Key Points

Cite This Study

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