Key result
Genetically determined higher BMI (1-SD increase) was associated with higher odds of current depression (OR 1.50; 95% CI 1.15-1.95) and lower well-being.
Why the study?
Higher adiposity is linked to psychiatric diseases, but whether this reflects metabolic consequences or psychosocial impacts remained unclear.
Does genetically determined higher adiposity increase the risk of depression and lower well-being in European adults?
Population
Up to 145 668 European participants from the UK Biobank
Comparison
Genetically determined higher adiposity vs lower adiposity
Design
One- and two-sample Mendelian randomization study
Authors
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Should not yet guide BMI interventions for depression; leaves open causal pathways for RCT confirmation.
Observational (n=145,668)
Does genetically determined higher adiposity increase the risk of depression and lower well-being in European adults?
Odds Ratio: 1.5 (95% CI 1.15–1.95)
Genetically determined higher adiposity is causally associated with increased odds of depression and lower well-being, independent of its adverse metabolic effects.
Casanova et al. (2021) conducted an observational in Depression and well-being (n=145,668). Higher adiposity (genetically determined higher BMI) vs. Lower adiposity was evaluated on Current depression (OR 1.50, 95% CI 1.15-1.95). Genetically determined higher BMI (1-SD increase) was associated with higher odds of current depression (OR 1.50; 95% CI 1.15-1.95) and lower well-being.
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