Key result
Multiple coronary artery ligations in rabbits caused a monotonic drop in fractional shortening from 40% to 28% and ejection fraction from 73% to 58% at 12 weeks, validating the ischemic heart failure model.
Absolute Event Rate: 28% vs 40%
p-value: p=<0.05
Multiple coronary artery ligations in rabbits create a reproducible model of ischemic heart failure characterized by progressive LV dysfunction, vascular rarefaction, and cardiac fibrosis.
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Validates rabbit model of progressive ischemic HF; leaves open translation to human therapies pending further study.
Wu et al. (2017) studied Myocardial infarction and ischemic heart failure (n=40). Multiple coronary artery ligations vs. Sham surgery was evaluated on Fractional shortening at 12 weeks (p=<0.05). Multiple coronary artery ligations in rabbits caused a monotonic drop in fractional shortening from 40% to 28% and ejection fraction from 73% to 58% at 12 weeks, validating the ischemic heart failure model.
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