Why the study?
Does lidocaine trigger malignant hyperthermia in MH-susceptible pigs?
Does lidocaine trigger malignant hyperthermia in MH-susceptible pigs?
Lidocaine does not trigger malignant hyperthermia in susceptible pigs, suggesting it is safe in this context.
Answers are grounded in this paper and cite their sources.
Lidocaine appears non-triggering in MH-susceptible pigs; leaves open human safety and requires clinical validation.
Lidocaine, considered by some to be potentially dangerous in malignant hyperthermia (MH), was administered intravenously to a dose of 15 mg/kg to five conscious MH-susceptible pigs. Subsequently the same pigs were given 24 mg/kg intravenously over a period of 2 hours after being anesthetized with thiopental. All animals developed systemic toxicity to lidocaine but without evidence of MH. Prior administration of lidocaine did not prevent development of subsequent MH due to succinylcholine and halothane. Lidocaine is safe in porcine MH.
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Wingard et al. (1979) studied this question.
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