Key result
A single 500 mg dose of standard Aspirin prolonged bleeding time and inhibited platelet aggregation for 6 days, whereas effects normalized by day 6 with enteric-coated formulations.
Why the study?
Do different formulations of a single 500 mg dose of acetylsalicylic acid have differing effects on platelet function tests in healthy young male subjects?
Population
Healthy young male subjects
Comparison
Single dose of 500 mg acetylsalicylic acid in 3… vs Baseline measurements
Design
Other
Follow-up
6 days
Authors
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Standard aspirin may sustain platelet inhibition longer than enteric-coated; leaves open clinical relevance for bleeding or thrombotic risk in patients.
Do different formulations of a single 500 mg dose of acetylsalicylic acid have differing effects on platelet function tests in healthy young male subjects?
A single dose of standard acetylsalicylic acid provides more sustained inhibition of platelet aggregation and prolongation of bleeding time over 6 days compared to enteric-coated formulations.
Kutti et al. (1984) studied Healthy. Acetylsalicylic acid (ASA) in 3 different formulations (Aspirin, Reumyl, Premaspin) vs. Baseline and between formulations was evaluated on Template bleeding time (TBT), ADP-induced platelet aggregation, and serum production of TXB2. A single 500 mg dose of standard Aspirin prolonged bleeding time and inhibited platelet aggregation for 6 days, whereas effects normalized by day 6 with enteric-coated formulations.
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