Key result
A fixed combination of bisoprolol and amlodipine achieved target blood pressure in 84.2% of patients with COPD and hypertension at 12 weeks, without negatively impacting lung function.
Why the study?
Does a fixed combination of bisoprolol and amlodipine improve blood pressure without negatively impacting lung function in patients with COPD and hypertension?
Does a fixed combination of bisoprolol and amlodipine improve blood pressure without negatively impacting lung function in patients with COPD and hypertension?
A fixed combination of bisoprolol and amlodipine effectively lowers blood pressure without worsening lung function in patients with concurrent hypertension and COPD.
Supports consideration of fixed bisoprolol-amlodipine in COPD-hypertension; hypothesis-generating, needs RCTs before practice change.
The purpose of this study was to assess efficacy of a fixed combination of bisoprolol and amlodipine (Concor AM, Takeda) in patients with chronic obstructive pulmonary disease (COPD) and hypertension (H). Methods . Thirty eight stable patients with stage 2 COPD and stage I–II H were treated with a fixed combination of bisoprolol and amlodipine. 24h ambulatory blood pressure monitoring (ABPM), electrocardiography, echocardiography, and lung function were performed at the baseline and in 12 weeks of therapy. Results . Thirty four (89.5%) patients continued the treatment after 12 weeks. The therapy with the fixed combination of bisoprolol and amlodipine in average dose of 7.5 / 10 mg/day provided a target blood pressure (BP) level in 32 (84.2%) patients. ABPM analysis demonstrated stable significant improvement in BP parameters including the heart rate variability. A trend toward normalization of the left heart diastolic function was noted during treatment. Lung function did not differ significantly before and after 12 weeks of the treatment indicating that the fixed combination of bisoprolol and amlodipine did not impact negatively on bronchial obstruction. Conclusion. The results confirm the rationale of therapy with the fixed combination of bisoprolol and amlodipine in patients COPD and H.
No takes yet. Share an insight, caveat, or question.
Никитин et al. (2015) studied chronic obstructive pulmonary disease (COPD) and hypertension (n=38). Fixed combination of bisoprolol and amlodipine was evaluated on target blood pressure (BP) level. A fixed combination of bisoprolol and amlodipine achieved target blood pressure in 84.2% of patients with COPD and hypertension at 12 weeks, without negatively impacting lung function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: