Key result
Cancer cachexia in colorectal cancer patients was associated with significantly higher peritumoural adipose tissue levels of TNF-α, STAT-1, and FADD compared to weight-stable cancer.
Observational (n=16)
Inflammatory and tumorigenic pathways are altered in the peritumoural adipose tissue of patients with cancer cachexia, with inflammatory cytokines correlating with growth factors.
Highlights peritumoural adipose inflammation in colorectal cancer cachexia; hypothesis-generating and should not yet change practice.
BACKGROUND: Cancer cachexia (CC) is a multifactorial syndrome, often irreversible, that affects patients with cancer influenced, in part, by the inflammatory condition. Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, and growth factors; given the possible crosstalk between the peritumoural adipose tissue and tumour, these may play an important role in cancer biology and carcinogenesis. METHODS: The aim of this study was to evaluate the factors produced by peritumoural adipose tissue in a cohort of 16 colorectal cancer patients with either weight-stable cancer (WSC; n = 7) or CC (n = 9). The study was approved by the Ethics Research Committee (972.914). Samples of peritumoural adipose tissue were analysed for concentrations of TNF-α, IL-1β, STAT-1, STAT-3, RANTES, IL-1Ra, IP-10, IL-15, MCP-1, IFN-α, GCSF, FADD, and TGF-β. The cytokines and proteins were measured using Multiplex. Correlations between the proteins and cytokines were evaluated. RESULTS: TNF-α, STAT-1, and FADD, a factor involved in apoptosis, were significantly higher in CC group than in the WSC group. In the peritumoural adipose tissue of the CC group, RANTES showed a significant positive correlation with IL-1Ra and IP-10 and a negative correlation with IFN-α; and GCSF showed significant negative correlations with IL-1Ra, IP-10, IL-15, and MCP-1 and a positive correlation with IFN-α. In the peritumoural adipose tissue of the WSC group, no significant correlations were detected between RANTES, GCSF, IL-3, FADD, and STAT-1 and the cytokines/chemokines analysed. CONCLUSIONS: These results indicated that inflammatory and tumorigenic pathways were altered in peritumoural adipose tissue in CC. Furthermore, inflammatory cytokines were correlated with growth factors in the peritumoural adipose tissue of cachectic patients, suggesting that inflammatory cytokines modulated the proliferative environment closely linked to the tumour.
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Neto et al. (2018) conducted an observational in Colorectal cancer (n=16). Cancer cachexia vs. Weight-stable cancer was evaluated on Concentrations of peritumoural adipose tissue cytokines and proteins. Cancer cachexia in colorectal cancer patients was associated with significantly higher peritumoural adipose tissue levels of TNF-α, STAT-1, and FADD compared to weight-stable cancer.
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