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January 1, 2016Cellular Physiology and BiochemistryOpen Access

Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis via Nrf2-Mediated Inhibition of TGF-β1/Smad3 Pathway in Myocardial Infarction Mice

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Key result

The CB2 receptor agonist AM1241 improved cardiac function and alleviated myocardial interstitial fibrosis in mice with MI via Nrf2-mediated down-regulation of the TGF-β1/Smad3 pathway.

Population

Mice with myocardial infarction and primary cultured cardiac fibroblasts subjected to hypoxia/serum…

Design

Preclinical

Authors

XLXiang LiFudan UniversityDHDong HanCivil Aviation Administration of ChinaZTZuhong TianNational Clinical Research Center for Digestive Diseases

Discussion

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Implication

Should not yet change post-MI care; leaves open CB2 agonism as a hypothesis-generating target for human remodeling trials.

Structured PICO

P
Population
Mice with myocardial infarction (MI) and primary cultured cardiac fibroblasts subjected to hypoxia/serum deprivation (H/SD) injury
I
Intervention
AM1241 (CB2 receptor selective agonist)
O
Outcome
Cardiac function (assessed by echocardiography) and expression of fibrosis markers (collagen I, collagen III, fibronectin, PAI-1, TIMP-1)surrogate

Activation of the CB2 receptor by AM1241 ameliorates myocardial fibrosis and improves cardiac function post-myocardial infarction in mice via the Nrf2/TGF-β1/Smad3 pathway.

Cite This Study

Li et al. (2016) studied Myocardial infarction. AM1241 was evaluated on Cardiac function and myocardial interstitial fibrosis markers. The CB2 receptor agonist AM1241 improved cardiac function and alleviated myocardial interstitial fibrosis in mice with MI via Nrf2-mediated down-regulation of the TGF-β1/Smad3 pathway.

synapsesocial.com/papers/6a99b7f80885b2e474a86066https://doi.org/10.1159/000447855
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