July 18, 2007Journal of VirologyOpen Access

Horizontal Transmission of Marek's Disease Virus Requires U S 2, the U L 13 Protein Kinase, and gC

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Population

Specific-pathogen-free chickens and chicken embryo/kidney cell cultures

Comparison

Infection with recombinant Marek's disease… vs Infection with original pRB-1B-derived virus or…

Design

Preclinical, Chickens were assigned to treatment groups using a randomized table

Follow-up

up to 63 days post-infection

Authors

KJKeith W. JarosinskiUniversity of Illinois Urbana-Champaign NMNeil G. MargulisDartmouth College JKJeremy P. KamilBoston University

Discussion

Member takes

Implication

May inform MDV control in poultry; leaves open extension to other herpesviruses or interventions.

Structured PICO

Population

Specific-pathogen-free (SPF) chickens (P2a, major histocompatibility complex: B19B19) and chicken embryo/kidney cell cultures

Intervention

Infection with recombinant Marek's disease viruses (MDV) with repaired genes (US2, UL13, gC, gD) derived from pRB-1B BAC

Comparator

Infection with original pRB-1B-derived virus (v1193) or wild-type MDV strain RB-1B

Outcome

Horizontal transmission of MDV to contact chickens, viral replication (viremia levels), and Marek's disease (MD) incidence

The study identifies that the combination of US2, UL13, and gC genes is essential for the horizontal transmission of Marek's disease virus in chickens.

Cite This Study

Jarosinski et al. (2007) studied this question.

synapsesocial.com/papers/6a99b8be1501ecb4bce2758a https://doi.org/10.1128/jvi.01065-07

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Horizontal Transmission of Marek's Disease Virus Requires U S 2, the U L 13 Protein Kinase, and gC

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Horizontal Transmission of Marek's Disease Virus Requires U S 2, the U L 13 Protein Kinase, and gC

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider