Key result
Lower sodium excretion (≤100 mmol/day) in patients with chronic kidney disease is associated with better blood pressure control and lower proteinuria compared to high sodium excretion.
Why the study?
Does sodium restriction reduce mortality and slow progression of renal disease in patients with chronic kidney disease?
Does sodium restriction reduce mortality and slow progression of renal disease in patients with chronic kidney disease?
While sodium restriction in CKD improves blood pressure and proteinuria, its long-term impact on mortality and renal disease progression remains an unsolved challenge.
According to current nutritional recommendations, patients with chronic kidney disease (CKD) should restrict their salt intake and eat <90–100 mmol sodium (Na) per day [5–6 g sodium chloride (NaCl)/day]. The scientific basis of this recommendation is the strong evidence of a beneficial effect of reducing salt intake on two major targets of CKD management, namely blood pressure (BP) and proteinuria. Indeed, when compared with patients with a high urinary Na excretion, CKD patients with a lower Na excretion (≤100 mmol/day) had better BP control and lower proteinuria [1, 2]. Experimentally there is also increasing evidence that a high Na intake may have a detrimental effect on renal function, independent of BP, through direct effects on inflammatory processes and immune balance [3, 4]. However, evidence that being on a low salt diet reduces mortality and slows the progression of renal diseases in CKD is still...
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Burnier et al. (2020) conducted a review in chronic kidney disease. Sodium restriction (≤100 mmol/day) vs. High sodium intake was evaluated. Lower sodium excretion (≤100 mmol/day) in patients with chronic kidney disease is associated with better blood pressure control and lower proteinuria compared to high sodium excretion.
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