What question did this study set out to answer?

Identify and characterize circulating rotavirus strains causing acute diarrhea in pediatric patients.

June 1, 2003Journal of Clinical MicrobiologyOpen Access

Emergence of Novel Human Group A Rotavirus G12 Strains in India

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Population

454 stool samples from children below 4 years of age and patients of all age groups with diarrhea collected…

Design

Cross-sectional

Authors

SDSoma DasAdamas University VVVici VarghesePost Graduate Institute of Medical Education and Research SCSanjeev ChaudhuryDr. Rajendra Prasad Government Medical College

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Implication

Emerging G12 strains in India support ongoing surveillance; leaves open implications for rotavirus vaccine coverage.

Key Points

Identify and characterize circulating rotavirus strains causing acute diarrhea in pediatric patients.
Screened clinical diarrhea samples from infants under 8 months of age during routine rotaviral surveillance.
Sequenced and analyzed the VP7 genes of isolated strains to determine nucleotide and amino acid homology against reference strains.
Detected three rare human group A rotavirus G12 strains in clinical diarrhea samples.
Demonstrated that the VP7 genes exhibited 97% to 99% nucleotide homology and 98% amino acid homology with contemporary G12 strains from the United States and Thailand, but lower homology with prototype G12 strain L26.

Structured PICO

Population

454 stool samples from children below 4 years of age and patients of all age groups with diarrhea collected from multiple hospitals in India (Calcutta, Dibrugarh, Bhubaneshwar, Chandigarh) in 2001.

Outcome

Detection and genetic characterization (VP7 and VP4 genotyping) of rotavirus strains

The detection of three G12 rotavirus strains in India highlights the emergence and genetic variability of this rare strain, which is important for future vaccine design.

Limitations

Very few strains detected and sequenced

Cite This Study

Das et al. (2003) studied this question.

synapsesocial.com/papers/6a99b9d954c4ab2d0d0946eb https://doi.org/10.1128/jcm.41.6.2760-2762.2003

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Emergence of Novel Human Group A Rotavirus G12 Strains in India

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Emergence of Novel Human Group A Rotavirus G12 Strains in India

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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