An efficient synthesis of 3,4‐dihydropyrimidinones from aldehyde, β‐keto ester and urea in ethanol using cobalt chloride hexahydrate or lanthanum chloride heptahydrate as a catalyst was described. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields (56%‐99%) as well as short reaction time (4–5 h).
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Lü et al. (2002) studied this question.
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