Key result
Short-course postoperative antibiotic therapy for complicated intra-abdominal infections was safe, while the frequency of long-course therapy declined from 48.1% to 26.3% without clinical benefits.
Why the study?
Recent evidence suggests short-course postoperative antibiotic therapy for intra-abdominal infections is non-inferior, prompting a comparison of short versus long therapy in complicated intra-abdominal infections without sepsis.
Does short-course postoperative antibiotic therapy improve clinical outcomes compared to long-course therapy in complicated intra-abdominal infections without sepsis?
Population
260 cases of complicated intra-abdominal infections without sepsis after emergency surgery with adequate source control
Comparison
Short vs long duration postoperative antibiotic therapy
Design
Single-center quality improvement study
Authors
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May support shorter courses after source control; leaves open randomized confirmation before practice change.
Cohort (n=260)
No
Does short-course postoperative antibiotic therapy improve clinical outcomes compared to long-course therapy in complicated intra-abdominal infections without sepsis?
Short-course antibiotic therapy after successful surgical source control in complicated intra-abdominal infections is safe and avoids the higher postoperative morbidity associated with longer duration therapy.
Surat et al. (2022) conducted a cohort in Complicated intra-abdominal infections (cIAIs) without sepsis (n=260). Short-course postoperative antibiotic therapy vs. Long-course postoperative antibiotic therapy was evaluated on Clinical outcome and postoperative morbidity. Short-course postoperative antibiotic therapy for complicated intra-abdominal infections was safe, while the frequency of long-course therapy declined from 48.1% to 26.3% without clinical benefits.
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