Key result
Transdermal absorption of propylene glycol from topical silver sulfadiazine produced hyperosmolality with a peak concentration of 1,059 mg/dL, potentially contributing to cardiorespiratory arrest.
Population
1 infant with a burn and toxic epidermal necrolysis involving 78% of total body surface area.
Design
Case_report
Authors
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May signal propylene glycol toxicity risk with silver sulfadiazine in infants; hypothesis-generating and should not yet change practice.
Case Report (n=1)
Transdermal absorption of propylene glycol from topical silver sulfadiazine can cause severe hyperosmolality and potentially cardiorespiratory arrest in infants with extensive skin barrier loss.
Corinne L. Fligner (1985) conducted a case report in Burn and toxic epidermal necrolysis (n=1). Topical silver sulfadiazine (containing propylene glycol) was evaluated on Propylene glycol concentration and osmolal gap. Transdermal absorption of propylene glycol from topical silver sulfadiazine produced hyperosmolality with a peak concentration of 1,059 mg/dL, potentially contributing to cardiorespiratory arrest.
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