Asymmetric Total Synthesis of (+)-7-Deoxypancratistatin

All articles of this category An asymmetric synthesis of 7-deoxypancratistatin 1 has been accomplished starting from diol 2 via two pathways in overall yields of 2.6 and 3.0%, respectively. The key step involved the regioselective ring opening of tosylaziridine 3 or the new carbomethoxyaziridine 15 with a higher-order cuprate and the cyclization of urethane 11 . 3-Bromo-3,5-cyclohexadiene-1,2-diol - vinylaziridine - higher-order cuprate - Bischler-Napieralski cyclisation